Incidence of colon and rectal cancer in selected countries in Latin America

Abstract

TPS 723: Low and middle income countries: sanitation infections and other health effects, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM Background. Over the past decades, incidence trends of colorectal cancer increased in Latin America. Aim.To estimate the effects of Age-Period-Cohort (APC) over the colorectal cancer incidence rates in Latin American countries covered by high-quality population-based cancer registries.Methods. A trend study using Cancer Incidence in Five Continents(CI-5) published by International Agency for Research on Cancer(IARC) of 1983-2012 in Cali(n=5.528), 1983-2007 in Costa Rica(n=8.585), of 1988-2012 in Goiania(n=3.856) and Quito(n=2463) was performed. APC effects were estimated including people aged 20-79, using Poisson regression model, with 5% significance level. Models adjustment were evaluated by statistics deviance.Results: Age effects for both sexes across every region and anatomic sites were observed. Curves inclination reached peaks in older groups (70-74 and 75-79 years). Cohort effects were observed in all regions, with increased RR for the more recent cohorts. For colorectal cancer increases were observed in men and women in Cali(RR=4.16;CI95%:2.29-7.55 and RR=3.77;CI95%:2.12-6.69), Costa Rica(RR=2.51;CI95%:1.50-4.20 and RR=2.17;CI95%:1.30-3.61), Goiania(RR=4.68;CI95%:2.18-10.02 and RR=2.65;CI95%:1.31-5.36) and for men from Quito(RR=2.61;CI95%:1.10-6.16). For colon cancer effects were observed in men and women of Cali(RR=4.26;CI95%:1.89-9.63 and RR=3.62;CI95%:1.68-7.80), Costa Rica(RR=2.66;CI95%:1.37-5.18 and RR=3.41;CI95%:1.79-6.50), Goiania(RR=1.26;CI95%:1.15-1.38 and RR=1.23;CI95%:1.25-1.34) and Quito(RR=3.19,CI95%:1.04-9.77 and RR=1.86;CI95%:1.06-3.26). For rectal cancer, there were increases in men and women in Cali(RR=4.03;CI95%:1.67-9.73 and RR=3.40;CI95%:1.49-7.76), Goiania(RR=3.25;CI95%:1.04-10.18 and RR=4.60;CI95%:1.61-13.09) and in men from Costa Rica(RR=2.41;CI95%:1.07-5.44) and Quito(RR=1.71,CI95%:1.05-2.77). Increased period effects was observed for colorectal cancer in 2003-2007 among men and women of Goiania(RR=1.26; CI95%:1.17-1.35 and RR=1.24;CI95%1.16-1.32), colon cancer(RR=1.26;CI95%:1.15-1,38 and RR=1.23;CI95%:1.25-1;34), and rectal cancer(RR=1.27;CI95%:1.14-1.42, and RR=1.25;CI95%:1.13-1.38).Conclusions: In Latin America, an age effect was observed in the increased incidence rates for every anatomic site. Birth cohort effects were verified for recent cohorts in both gender for all site in Cali and Goiania; while in Costa Rica was observed for colorectal and colon cancer, in both gender, and rectal among men and in Quito. Goiania city presented a period effect with increased RR for 2003-2007.