Inbreeding Coefficient and Distance in MHC Genes of Parents as Predictors of Reproductive Success in Domestic Cat.

Abstract

Simple SummaryInbreeding and low diversity in MHC (major histocompatibility complex) genes can have a significant impact on the survival and quality of offspring in mammals. At the same time, a decrease in genetic diversity can be disastrous for animals at individual and species level. For felines, studies of the effects of inbreeding and low variety in MHC genes are conducted on populations with a low number of animals, where there is a high probability of a shortage of available partners, and, accordingly, their choice. The use of model species, especially domestic cats, allows us to identify the main consequences of inbreeding and the lack of a choice of partners for future offspring. The survival of offspring in a domestic cat is primarily affected by the degree of similarity/difference in the genes of the parents’ MHC. Parents with the maximum distance in MHC genes have a larger proportion of surviving kittens, and this effect is most pronounced immediately after birth. In parents with the minimum distance in MHC genes, a significant percentage of kittens are either stillborn or die on the first day after birth. However, inbreeding and the similarity of parents in MHC genes in domestic cats did not affect the body mass of kittens.Inbreeding and low diversity in MHC genes are considered to have a negative effect on reproductive success in animals. This study presents an analysis of the number and body mass of offspring in domestic cat, depending on the inbreeding coefficient and the degree of similarity in MHC genes of class I and II in parents. Inbred partners had a lower number of live kittens at birth than outbred ones. At the same time, the inbreeding coefficient did not affect the litter size and the number of offspring who survived until the period of transition to solid food. The most significant predictor for the number of surviving offspring was the degree of parental similarity in MHC genes: the parents with the maximum distance in MHC genes had more survived kittens. Moreover, this effect was most pronounced immediately after birth. A significant percentage of kittens from parents with a minimum distance in MHC genes were either stillborn or died on the first day after birth. By the age of transition to solid food, this effect is no longer so pronounced. Furthermore, neither the inbreeding coefficient nor the distance in MHC genes of parents had any effect on the body mass of kittens.