Abstract
The in vivo effect of garlic oil on protein, glycogen and lipid metabolism as well as on oxidative phosphorylation has been studied in liver and kidneys of mice. The incorporation of [ 14C] leucine into proteins of the liver is virtually unchanged by treatment with garlic oil whereas the labelling of proteins of the kidneys is reduced. Garlic oil enhances the incorporation of [ 14C] glucose into hepatic glycogen, produces a temporary rise in blood glucose levels and depletes liver glycogen. Renal glycogen levels and incorporation of [ 14C] glucose into renal glycogen remain unchanged following garlic oil treatment. The compound has little or no effect on the incorporation of [ 14C] acetate into hepatic and renal lipids. Garlic oil impairs partially the oxidative phosphorylation associated with the oxidation of ascorbate in hepatic mitochondria without affecting noticeably the P/O ratio during the oxidation of glutamate and succinate.
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