Abstract
With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids in vitro as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in vivo in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.
Highlights
With diabetes being the 7th leading cause of death worldwide affecting nearly 10% of the world's population, with a quadrupling of its prevalence since 1980,1 and accounting for almost 15% of direct healthcare costs,[2] its treatment is of global signi cance.[3]
Following oral administration of TTADFP-nanoscale imine-linked covalent organic frameworks (nCOFs)/insulin (50 IU kgÀ1), a signi cant reduction in blood glucose levels similar to that in non-diabetic rats was observed within 2 h coupled with a sustained hypoglycemic effect for 10 h, replicating the normal glucose level of the nondiabetic control group (Fig. 3a)
Diabetes mellitus is o en associated with alterations of kidney and liver functions in rats; we studied the impact of TTA-DFP-nCOF/insulin on these vital functions.[99]
Summary
With diabetes being the 7th leading cause of death worldwide affecting nearly 10% of the world's population, with a quadrupling of its prevalence since 1980,1 and accounting for almost 15% of direct healthcare costs,[2] its treatment is of global signi cance.[3]. TEM, PXRD and BET analysis of the nCOF a er insulin release under hyperglycemic conditions showed a decrease in size, restoration of the crystallinity to a certain degree, and increased BET surface area compared to TTA-DFP-nCOF/insulin (Fig. S35 and S36†).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
