Abstract
BACKGROUND: Inhibition of intestinal maltase and sucrase prevents postprandial blood glucose excursions which is beneficial in ameliorating diabetes-associated complications. OBJECTIVE: In this study, the inhibitory effects of fruit extracts of Parinari macrophylla, Detarium microcarpum, Ziziphus spina-christi, Z. mairei and Parkia biglobosa were investigated against intestinal maltase and sucrase. METHODS: Rats were given co-administration of the fruit extracts with maltose or sucrose and blood glucose levels were measured at 0, 30, 90 and 120 min. RESULTS: The glucose-time curves indicated that all the fruits had the most potent inhibitory effects on both maltase and sucrase within the first 30 min. The computed Area Under the Curves (AUC0–120) for all the fruits indicated more potent inhibitory effects against intestinal maltase than sucrase. The ED50 range for the fruits extract against maltase and sucrase were 647.15–1118.35 and 942.44–1851.94 mg/kg bw respectively. CONCLUSION: The data suggests that the fruits could prevent postprandial hyperglycemia via inhibition of intestinal maltase and sucrase.
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