Abstract
We present results of main skin chromophores (melanin and hemoglobin) optical analysis. Analysis of 91 in vivo skin tissues (50 benign and 41 malignant) was performed in visible spectral region with hyperspectral imaging technique. To assess the malignancy of skin tissues we proposed two methods for calculating the integral index of tissue optical density and performed a comparison of their effectiveness and effectiveness of physician survey. As the main diagnostic feature, we propose to use data of integral optical index dispersion from the studied tissue and healthy tissue area. The results of skin tissues classification with discriminant analysis are presented. The possibility of the proposed approaches application in the clinical practice is shown.
Highlights
Cancer is one of the most dangerous and yearly progressing diseases
Differentiation of BN pathologies from malignant neoplasms is possible with backscattered spectrum analysis in the visible region since it contains data on hemoglobin and melanin content in skin tissues
These distributions may help classify neoplasms based on quadratic discriminant analysis (DA) implementation
Summary
Cancer is one of the most dangerous and yearly progressing diseases. According to the International Agency for Research on Cancer, about 14.1 million new cases of cancer have been detected throughout the world in 2012, and the estimated increase of new cancers by 2025 is up to 19.3 million cases due to the growth of the population and the increase in its average age [1]. Skin cancer is one of the most common forms of cancer [2]. Basal cell carcinoma of the skin is the most common type of cancer in the world and accounts for about 75% of all malignant skin formations. On the contrary, has the lowest incidence rate in the world (9%) but ranks first in mortality (75%) among all forms of skin cancer [3]. According to the Moscow Scientific Research Institute of Oncology named after P.A. Hertsen, the incidence of malignant neoplasms in Russia in 2015 was 589 341 cases. The increase in the incidence of malignant skin tumors from 2005 to 2015 is 31.47%, including a 34.84% increase in melanoma cases
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