Abstract
To estimate left ventricular muscle mass for diagnosis in cardiac disease a coronary sinus catheter was developed that combines repetitive serial measurement of hydrogen concentration and thermodilution blood flow for estimation of left ventricular mass. The temperature of the injected indicator is measured by a thermistor within the lumen of a coronary sinus catheter. A platinum band encircling the catheter measures hydrogen concentration. Blood and blood-injectate temperature is measured by a thermistor appended to the outside of the band. The rate at which hydrogen leaves the tissue and is detected in venous blood depends directly on the rate of blood flow and inversely on the mass of tissue. Single exponential hydrogen washout curves were obtained and the washout rate constant measured at the same time thermodilution flows were recorded. Live dogs, pigs, and calves were catheterized using this instrument and each ventricle weighed after death. Calculated weights and actual weights showed a correlation coefficient of 0·973; p< 0·001.
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