Abstract
In recent years, probiotics of human origin have shown superior results and performance compared to probiotics from plant or dairy sources, in both in vitro and animal studies. Towards this end, the current study was conducted to explore the ergogenic properties of Bifidobacterium longum subsp. longum OLP-01 isolated from the intestinal microbiome of the gold medalist from the 2008 Beijing Olympics women’s 48 kg weightlifting competition. Male Institute of Cancer Research (ICR) mice were divided into four groups (n = 10 per group) and orally administered OLP-01 for 4 weeks at 0 (vehicle), 2.05 × 109 (OLP-01-1X), 4.10 × 109 (OLP-01-2X), and 1.03 × 1010 (OLP-01-5X) CFU/kg/day. Physical performance tests including grip strength and endurance time were measured, with OLP-01 supplementation dose-dependently elevating grip strength and endurance. The anti-fatigue activity levels of serum lactate, ammonia, glucose, blood urea nitrogen (BUN), and creatine kinase (CK) were measured after an acute exercise challenge, and OLP-01 was found to significantly decrease lactate, ammonia, and CK levels. OLP-01 treatment was also found to significantly increase the resting levels of both hepatic and muscular glycogen, an indicator of energy storage. Supplementation by OLP-01 showed no subchronic toxic effects while supporting many health-promoting, performance-improving, and fatigue-ameliorating functions.
Highlights
Exercise increases the alpha diversity of the microbiome of individuals and decreases the thick-walled bacteria, and Clostridium is considered to be one of the main factors regulating the composition and health of intestinal microbial diversity [1]
The results showed no significant differences in the 4 week growth curves of the vehicle, OLP-01-1X, OLP-01-2X, and OLP-01-5X groups (Figure 1)
Relative epididymal fat pad (EFP) weight was significantly lowered by 23.44% (p = 0.0376), 25.04% (p = 0.0255), and 23.60% (p = 0.0338) with 1X, 2X, and 5X OLP-01 supplementation, respectively, compared to the vehicle group
Summary
Exercise increases the alpha diversity of the microbiome of individuals and decreases the thick-walled bacteria, and Clostridium is considered to be one of the main factors regulating the composition and health of intestinal microbial diversity [1]. Exercise promotes the energy harvesting functions of gut microbiota such as antibiotic biosynthesis, amino acid utilization, carbohydrate metabolism, and production of fecal metabolites, e.g., short-chain fatty acids (SCFAs). This leads to enhanced muscle turnover, adaptation, and improved exercise performance. The development and application of human-origin probiotics has increasingly received attention as many studies have shown their superior results and performance in both in vitro and animal studies, compared to probiotics from plant and dairy sources This appears to be the current trend in the development of probiotics [12,13]
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