Abstract
The in vivo effects of di- n-butyltin dichloride (DBT) on the enzyme activity and lipid constituents of liver plasma membrane were studied in male Albino rats. The rats were intraperitoneally administered with 0.1 ml (10% v/v) ethanol either alone or containing DBT (10 or 30 mg/kg/d) for 7 consecutive days. A significant inhibition of plasma membrane marker enzymes such as 5'-nucIeotidase, y-glutamyltranspeptidase, alkaline phosphatase, Mg 2++-ATPase, Na +/K +-ATPase and Ca 2+-ATPase occurred in DBT-treated rats when compared with respective controls. Other important bioconstituents such as sialic acid and total phospholipid/cholesterol ratio were also significantly decreased in DBT-treated rats when compared with corresponding controls. These results suggest that interaction of DBT with liver plasma membrane constituents might cause derangement of its structural and functional organization, thus leading to hepatotoxicity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
