Abstract
The methanol extract of stem bark of Detarium microcarpum and Myosortisscorpioides were screened for in vivo safety pharmacological studies (acute toxicity LD50) using Swiss Albino Miceand for the presence of some phytochemicals. The result of the phytochemical screening indicated the presence of important secondary metabolites including alkaloids, saponins, tannins, anthraquinones, carbohydrates, flavonoids. The results showed that the plant extracts were toxic to the mice and caused death at a concentration of =2900mg/Kg and 1600mg/kg body weight of the live mice and LD50 of 3,807.89mg/Kg and =2,828.43mg/Kg respectively. The result of the study was a useful guide to a practically safe dose in an ongoing antimalarial study of extracts of these plants.
Highlights
Paracelsus once said, “All substances are poisons; there is none which is not a poison
Necessities of toxicological studies include the benefit of calculation of risk ratio and the prediction of therapeutic index obtained as ratio of maximum tolerated dose and minimum curative dose as expressed by following equation; Therapeutic index = (Maximum tolerated dose)⁄(Minimum curative dose)
The present study is an effort to further investigate the Chemistry and Pharmacology of Detarium microcarpum and Myosortisscorpioidesto justify the claim of traditional medicine practitioners in the area of study (Adamawa State - Nigeria)
Summary
Paracelsus once said, “All substances are poisons; there is none which is not a poison. The present in vivo safety pharmacology study was designed to define the dose-response relationship of the adverse effect of the plant extracts and the time course of the adverse effect e.g. onset and duration of response was investigated. In the present study extracts of the plants under investigation were administered at different dose levels, and the effects were observed for 14 days. Medicinal properties are in the roots, stems, bark, leaves and fruits to treat ailments including tuberculosis, Curr Trends Biomedical Eng & Biosci 14(4): CTBEB.MS.ID.555891 (2018). It is native to Europe and Asia, but can be found elsewhere, including Africa and much of North America, as an introduced species and sometimes a noxious weed It grows in bogs and wet places and beside streams and rivers. The present study is an effort to further investigate the Chemistry and Pharmacology of Detarium microcarpum and Myosortisscorpioidesto justify the claim of traditional medicine practitioners in the area of study (Adamawa State - Nigeria)
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