Abstract
In this study, the effectiveness of cobra venom factor and heterologous anti-C3 in depleting the various components of complement in guinea pigs was compared. Although C5 was abrogated in vivo after injection of cobra venom factor alone, circulating C3 could only be completely abolished by injection of heterologous anti-C3 subsequent to cobra venom factor treatment. Because of the need to fully abrogate C3 in order to study the role of this component in various immunopathological mechanisms, data relating to the use of both cobra venom factor and anti-C3 are presented.
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