Abstract
The anti-mycoplasma effects of the ionophores (lasalocid sodium, monensin and nigericin) were compared with that of tylosin tartrate and tiamulin in vitro. Forty-four strains representing 14 avian and 10 mammalian Mycoplasma species and serotypes and 5 Acholeplasma species were tested. The ionophores showed average minimal inhibitory concentration (MIC) values between 3.65 and 4.93 μg ml −1 for all strains, the MIC values for glucose-fermenting strains were between 2.26 and 3.75 μg ml −1, significantly lower than for arginine-hydrolysing strains (9.27–13.12 μg ml −1). These values were significantly higher than those obtained with tylosin tartrate (0.45 μg ml −1) or tiamulin (0.13 μg ml −1). The ionophores were more efficacious against acholeplasmas (0.06–0.25 μg ml −1) than against mycoplasmas.
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