Abstract
Introduction: - Long term soft liners (acrylic and silicone based) are used to prevent damage to the abused mucosa, but they have the disadvantage of becoming porous with time leading to a suitable environment for opportunistic infections. This study was aimed to examine the inhibitory effect of incorporation of antifungal drug clotrimazole into long term denture soft liners on the growth of Candida albicans in vitro and evaluate the change in the surface hardness of soft liners.Materials and Method: The present study was done for two different long term soft liners, acrylic based (Permasoft) and silicone-based (Mollosil), by addition of clotrimazole drug in their minimum inhibitory concentration. The properties –zone of inhibition and surface hardness(Shore A) were evaluated at time intervals of 1,7,14,21,35 and 42days. A total of 224 samples were prepared. The properties were analyzed and inter group and intra group data was analyzed statistically by using One way ANOVA, Tukey post hoc-test and Paired t test.Result: The results showed significant creation of zone of inhibition for samples containing clotrimazole with the zone of inhibition decreasing with time. The surface hardness of all the samples increases with time.
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