Abstract
At present, surgery remains the preferred treatment for hydatid cyst. Various chemical scolicidal agents have been used for inactivation of protoscoleces during surgery, but most of them are associated with adverse side effects. In this study we investigated the effect of two commercial grape and apple vinegar on the viability of hydatid cyst protoscoleces. The protoscoleces of E. granulosus were aspirated from the infected livers and lungs of sheep slaughtered at Tiaret abattoir. 0.5 mL of two commercial grape and apple vinegar was used for 5, 10, and 15 min in the experiments. 0.1% eosin staining assessed viability of protoscoleces. All tests were carried in triplicate. The mortality rates of protoscoleces were 100% after 5min, 10 min and 15 min of incubation with grape vinegar and apple vinegar. To conclude, the results of the present survey indicated high scolicidal activity of apple vinegar and grape vinegar against protoscoleces of hydatid cyst and can be used in hydatid cyst surgery. However, further studies will be needed to confirm these results by checking this scolicidal activity in an in-vivo model.
Highlights
IntroductionDogs and carnivores are the main host of this parasite and humans are infected by ingesting parasite eggs released from these animals (Sadjjadi et al, 2009)
The larval stage of the tapeworms belonging to the species complex Echinococcus granulosus sensu lato (s.l.) are the etiological agents of a globally widespread zoonotic disease known as cystic echinococcosis (CE) (Budke et al, 2006; WHO 2018; Laurimäe et al, 2019)
The aim of this study was to evaluate the effect of two commercial grape and apple vinegar against protoscoleces of hydatid cyst, to explore their potential as natural scolicidal agent
Summary
Dogs and carnivores are the main host of this parasite and humans are infected by ingesting parasite eggs released from these animals (Sadjjadi et al, 2009). Hydatidosis is recognized by long-term growth of hydatid cysts in the different organs (liver, spleen, lung, muscle and brain) of human and other intermediate hosts (Zhang et al, 2003; Rostami et al, 2016). The infection is usually diagnosed by imaging and serologic tests (Sadjjadi et al, 2009). Annual costs associated with cystic echinococcosis (CE) are estimated to be 3 billion US$ for treating cases and losses to the livestock industry can include liver condemnation, reduction in carcass weight, decrease of milk production and reduced fertility (WHO, 2018; Houshmand et al, 2019)
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