Abstract
Lysosomes incubated in vitro with influenza virus, underwent some structural changes after adsorption of the virus to lysosomal membranes. 1. 1. The apparent density of lysosomes was reduced. 2. 2. Apparent enzyme activities in lysosomes were elevated due to alteration of lysosomal membranes. 3. 3. Some proteins were released from lysosomal membranes (‘released proteins’) but hydrolytic enzymes were retained. These phenomena were induced by virus-attachment on lysosomal membranes and not by viral or lysosomal enzymic actions. 4. 4. Both released proteins and lysosomal membranes were solubilized in SDS-buffer, then reaggregated after dialysis to free them from SDS. The former did not exhibit any receptor activity for virus, but the latter did. Probably, proteins containing the receptor for influenza virus are not liberated from lysosomal membranes by virus-treatment.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
