Abstract
The chemiluminescence assay was used to study the phagocytosis of 3190 nm polystyrene latex particles by human granulocytes. The surface of the particles was modified by the adsorption of poloxamer blockcopolymers (coating). The relative phagocytic uptake was studied as a function of the molecular structure: the molecular weight and the lengths of the polyethylene oxide (EO) and the polypropylene oxide (PO) chains. Poloxamer polymers with short EO and PO chains were less effective in reducing phagocytosis. The protective effect was found to increase with increasing length of the EO or PO chains. Phagocytosis could be almost completely inhibited by polymers combining longest EO and PO chains (poloxamers 338 and 407). The observed reductions in in vitro phagocytic uptake were attributed to particle properties related to the thickness of the adsorbed layers, steric stabilization, and reduction in surface hydrophobicity.
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