Abstract
Anti-sickling activity of Elaeis guineensis jacq flowers was investigated to determine the capability of the plant to inhibit the polymerization of sickle cell hemoglobin, maintain membrane osmotic fragility and recover the Fe2+/Fe3+ ratio. Spectrophotometric technique was employed to determine the rate of sodium metabisulphite provoked HbSS erythrocytes polymerization. The profile for HbSS erythrocytes polymerization of test and control specimens demonstrated growing level of polymerization at three investigational concentrations (20mg/ml, 40mg/ml and 60mg/ml) while (80mg/ml, 100mg/ml, 120mg/ml) concentrations of the extracts showed pronounced anti-sickling activity through inhibition of HbSS gelation. The estimation of mean corpuscular fragility (MCF), which is the concentration of saline causing 50% hemolysis of the erythrocytes, revealed that the plant extract decreased the MCF values of the HbSS erythrocytes at all concentrations in comparison to the control. The Fe2+/Fe3+ investigation revealed an increase in the test groups when compared to the control. The aqueous extracts of Elaeis guineensis jacq flowers demonstrated towering potency in altering the polymerization of sickle cell hemoglobin at increased concentration, enhancement in Fe2+/Fe3+ ratio and maintaining erythrocyte membrane integrity.
Highlights
Drepanocytosis, a genetic disorder of the blood commonly called sickle cell disease is associated with formation of abnormal crescent or sickle shape by the erythrocytes and characterized with recurrent painful episodes and life-long anemia
The data in (Table 1) revealed that the plant extract decreased the mean corpuscular fragility (MCF) values of the HbSS erythrocytes at all concentrations when compared to the control
Which suggest that aqueous extract of E. guineensis flower possess strong anti-sickling potential while the results in (Table 2) showed the first three concentrations (20mg/ml, 40mg/ml and 60mg/ml) of the plant extracts increased the polymerization of the erythrocyte while the other concentrations (80mg/ml, 100mg/ml, 120mg/ml) of the extracts showed pronounced anti-sickling activity through inhibition of HbSS gelation
Summary
Drepanocytosis, a genetic disorder of the blood commonly called sickle cell disease is associated with formation of abnormal crescent or sickle shape by the erythrocytes and characterized with recurrent painful episodes and life-long anemia. Were among the nutrients implicated in the patients suffering from this disease for reduction of some pathological conditions of this ailment and perhaps improvement on the projection of its syndrome nutritional supplementation is sacrosanct These nutrients help to improve the oxygen attraction of the red blood cell thereby inhibiting the aggregation of the hemoglobin of sickle cell individuals
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