Abstract
The immunological properties of the rosette-forming cell populations in Fr 2, 2b, and 3 have been compared. The isolated RFC fractions from Fr 2 and 2b respond well in the absence of cell contact with the remaining FIC. In contrast, the RFC population from Fr 3 fails to respond in the absence of direct contact with the FIC population. Bone marrow RFC failed to respond under all test conditions. Stimulation in vitro for 42 hr changes the Fr 3 RFC into one with some of the response characteristics of Fr 2. The thymus cell requirements of the Fr 2 and Fr 3 responses are different. Fr 3 appears to need direct contact with a thymus-derived cell, whereas a trophic phenomenon can be attributed to the thymus cell requirements of Fr 2.
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