In vitro Haemopoietic progenitor cell responses in mice with the transplanted lymphoid tumour ABE-8

Abstract

BALB/c mice bearing the (transplanted) lymphoma induced by the Abelson virus developed increased levels of neutrophil-macrophage and eosinophil progenitor cells in the bone marrow and spleen. This was accompanied by a granulocytosis in the peripheral blood. Increase of granulocyte-macrophage progenitor cells appears to parallel the magnitude of leukaemic infiltration, as determined by assaying the numbers of leukaemic colony forming cells in the spleen and bone marrow using a selective cloning system. The phenomenon also was observed in athymic mice indicating that it is unlikely to be T-cell mediated. It was also reproduced using irradiated cells or a cell-free extract of the tumour implying that a humoral factor is responsible for these host responses.