Abstract
The feasibility and possibility of in vitro haematopoiesis for clinical use such as cell therapy or substitution therapy have been discussed for years. In this review, we summarized the most promising and efficient strategies for in vitro haematopoietic cells production: the three-dimensional aggregates of pluripotent stem cells called embryoid bodies, a co-culturing system using feeder cells, and an extracellular matrix-coated dish system. We discussed the terminal differentiation of various types of blood cells using pluripotent stem cells or by direct lineage conversion.
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