Abstract
99mTc-ethylene dicysteine diethyl ester (99mTc-ECD) is an established radiopharmaceutical used for brain perfusion imaging; however it does not have any recognized biological quality control to ascertain its in vivo efficacy. The present paper describes an in vitro enzymatic method that can be adapted as a regular biological quality control for ECD kit evaluation before its release for patient end use. The method involves reaction of 99mTc-ECD (< 74 MBq; 0.1 mg ECD) with pig liver esterase enzyme (≥ 20 mg/mL) yielding metabolites in quantitative yield post 1 h incubation. Methodology developed is precise for routine quality control analyses of ECD kits.
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