In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids

Abstract

(Stem Cell Reports 12, 431–440; March 5, 2019) In the originally published version of our manuscript, the legend to Figure S3 in the Supplemental Information was accidentally removed during the proofing process. To address this, we have now replaced the Supplemental Information with the correct version. We apologize for the oversight and for any resulting confusion. In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar OrganoidsKorogi et al.Stem Cell ReportsFebruary 14, 2019In BriefPulmonary surfactant secretion by alveolar type 2 (AT2) cells is crucial for alveolar homeostasis. Gotoh and colleagues generated Hermansky-Pudlak syndrome type 2 (HPS2) patient-derived iPSCs and their gene-corrected counterparts and differentiated them into alveolar organoids (AOs). In HPS2-AOs, aberrant lamellar bodies and impaired surfactant secretion were demonstrated. Human iPSC-derived AOs might be useful for investigating alveolar lung diseases. Full-Text PDF Open Access