Abstract
Aim: To isolate and identify Candida albicans and non-albicans Candida from various clinical specimen of Intensive care Unit and to investigate some virulence factors and perform their Anti- fungal susceptibility. Materials and Methods: Overall 32 isolates (12 Candida albicans and 20 non- albicans Candida spp.) were included in this study. Virulence factors were studied. In isolates, egg yolk agar was used for determining phospholipase activity, while sheep and human plasma used to determine coagulase activity, Sabouraud dextrose agar with sheep blood for hemolysin activity. Biofilm formation was detected by the tube adherence method. Results: In both Candida spp., it was found that hemolytic activity were higher next to phospholipases activity. It was also found that Coagulase activity were detected in Candida species found to be higher with sheep plasma compared to human plasma. Biofilm production was found to be less and mostly were from blood culture isolates. Conclusion: Knowledge of these virulence factors is an important tool to understand pathogenesis of candidiasis and in addition will help to explore new antifungal drug targets for improved therapeutic regimens.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Current Research and Review
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
