Abstract
Background: More studiesusing cobalt complexes as drugs areneeded. Results: The drug action oftwo cobalt salicylaldimines was determined. The complexes and amphotericin B (20mg/ml) inhibited Candida albicans at 9-15 and 21mm. This concentration of both ligands inhibited Staphylococcus aureus at 10mm and one ligand inhibited Escherichia coli at 9mm, but the complexes and ampicillin inhibited four bacteria at 9-20 and 21-26mm. The ligands were inactive against cancer and normal cells, but the complexes and doxorubicin provided IC50valuesof 28.18-54.19 and 9.66μM against MCF-7 cells and 15.76-20.49 and 36.42μM against BHK cells. Conclusion: The ligands' activity was much improved by complexation, although they remained substandard.
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