Abstract
Using the agar diffusion method, this study evaluated the in vitro antimicrobial activity of the commercial endodontic sealers Acroseal and Epiphany, a castor-oil based experimental sealer, Polifil, and a primer agent (Epiphany self-etching primer), against Enterococcus faecalis. Zinc oxide and eugenol cement (ZOE) served as control. Five wells per dish were made at equidistant points and immediately filled with the test and control materials. After incubation of the dishes at 37 degrees C for 24 h and 48 h, the diameter of the zones of microbial growth inhibition produced around the wells was measured (in mm) with a millimeter rule. After 48 h, the diameters of the zones of microbial growth inhibition were the same as those observed at 24 h, only the substances continued to diffuse. Epiphany and Polifil did not show antibacterial activity (no formation of zones of microbial growth inhibition). The primer produced the largest zones of inhibition (17.62 mm) followed by Acroseal (7.25 mm) and ZOE (7.12 mm). E. faecalis was resistant to Epiphany and Polifil, while the primer and Acroseal sealer were effective against this microorganism under the tested conditions.
Highlights
Successful root canal treatment requires proper cleaning and shaping of the root canal system, as well as hermetic sealing of the canal space with an inert, dimensionally stable and biologically compatible material [1]
The means and standard deviations of the zones of microbial growth inhibition for each substance tested against E. faecalis within a 24-h period were: Epiphany: 0.00, Primer: 17.62 ± 2.26, Acroseal: 7.25 ± 0.46, Polifil: 0.00, Zinc oxide and eugenol cement (ZOE): 7.12 ± 0.64
E. faecalis was resistant to Epiphany and Polifil, while the primer and Acroseal sealer were effective against this microorganism under the tested conditions
Summary
Successful root canal treatment requires proper cleaning and shaping of the root canal system, as well as hermetic sealing of the canal space with an inert, dimensionally stable and biologically compatible material [1]. The search continues for an endodontic sealer that fulfills the requirements for the ideal physicochemical and biological properties. The main objective of endodontic therapy is, to eliminate bacteria from infected root canals and to prevent reinfection. The use of improved calcium hydroxide-based “biological” sealers has been proposed for permanent seal of the root canal system [3]. A new calcium hydroxide-based sealer, Acroseal, has been introduced to the market [7]
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