Abstract
Chronic exposure of rats to CdCl2 altered the specific binding of [3H]imipramine to membranes from platelets and hypothalamus. There was a decrease in Bmax of 10–40% and a decrease in KD values of 30–40% as compared to the control group. In vitro studies on the inhibition of [3H]imipramine binding to membranes from human and rat platelets and hypothalamus by CdCl2 corroborate the in vivo results which imply that the imipramine binding protein contains Cd2+-sensitive groups.
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