Abstract
gen, the sugar residues (which confer 0 specificity and constitute the smooth, virulent side chains), and the stereochemical configuration between the cell-wall components all appear relatively unimportant for the expression of the cidal activity of the leukocytic extract. The possible presence of host antigens on fresh bacterial isolates and of serum in the in-vitro assay system, however, interfered with the cidal property. It is suggested that the cidal system of polymorphonuclear leukocytes may represent a defense mechanism in which a few related proteins could accomplish a number of tasks by interaction with a susceptible ligand on the unit bacterial cell wall. Bactericidal activity in extracts from polymorphonuclear leukocytes (PMNs) of several mam
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