Abstract
Dental caries is a chronic disease and is unique among humans and is caused due to the accumulation of biofilm, which is characterized by microbial activity. Streptococcus mutans releases enzymes like SortaseA, which play an important role in the adhesion of bacteria to the tooth surface. Mulberry, a natural product has shown anti-cariogenic activity, which may be because of various compounds present in the plant extract. One such compound is 1-DNJ, an alkaloid shown to suppress S.mutans. In the last few decades, docking analysis has been used to get an insight into mechanism of action of test compounds. In the present study, we explored to analyze the in-silico interaction of 1-DNJSortaseA complex and found the compound to be effective in the inhibition of adherence of S.mutans.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
