Abstract
Type 2 diabetes mellitus (T2DM) is the most common disease in developing countries. People with type-2 diabetes are at high risk of complications leading to disability and premature death. Procyanidin compounds in cinnamon have an insulin-like activity that can regulate normal blood sugar levels. This research aimed to investigate the interaction between α-glucosidase and α-amylase with procyanidin A and their potential for diabetes treatment therapy. Data mining receptor was downloaded from RCSB PDB and ligands from PubChem. Drug likeness properties were evaluated using SwissADME, while toxicity analysis was assessed using metatox. Molecular docking between α-glucosidase and α-amylase with procyanidin A was performed using HEX 8.0.0 and was visualized by Discovery Studio. Procyanidin A showed interaction with α-glucosidase by non-bonds interaction, including hydrogen, hydrostatic and hydrophobic bonds, while procyanidin A and α-amylase formed hydrogen and hydrophobic bonds. Procyanidin A is an alternative treatment for T2DM with a variety of supportive chemical bonds. Procyanidin A has an excellent ability to inhibit activity α-glucosidase and α-amylase in the process of breaking down glucose in the intestines.
Highlights
Diabetes Mellitus is one of the most contagious and fastest-growing public health problems worldwide
Type 2 diabetes mellitus is caused by the body that cannot respond to insulin, while gestational diabetes mellitus is caused by glucose intolerance during pregnancy
Molecular docking was performed between procyanidin compounds with α-glucosidase and αamylase to determine the interaction between ligands and proteins
Summary
Diabetes Mellitus is one of the most contagious and fastest-growing public health problems worldwide. This disease has a complex condition to treat and high care treatment costs. The causes of diabetes mellitus are distinguished into 4, type I diabetes, type II diabetes, gestational diabetes mellitus, and other types of diabetes mellitus. Diabetes mellitus type 1 was characterized by the damage of β cells due to autoimmune reactions. Type 2 diabetes mellitus is caused by the body that cannot respond to insulin, while gestational diabetes mellitus is caused by glucose intolerance during pregnancy. Other types of diabetes mellitus can be caused by genetic abnormalities, pancreatic disorders, to the influence of certain drugs or chemicals [2]
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