Abstract
We commend Chou et al for conducting this multicentered prospective study on vulnerability assessment before definitive chemoradiation for head and neck cancers. This study concluded that vulnerability, as measured by comprehensive geriatric assessment (CGA), was independently associated with poorer survival and higher treatment-related toxicities. 1 Chou W.C. Chang P.H. Chen P.T. et al. Clinical significance of vulnerability assessment in patients with primary head and neck cancer undergoing definitive concurrent chemoradiation therapy. Int J Radiat Oncol Biol Phys. 2020; 108: 602-611 Abstract Full Text Full Text PDF PubMed Scopus (15) Google Scholar Clinical Significance of Vulnerability Assessment in Patients with Primary Head and Neck Cancer Undergoing Definitive Concurrent Chemoradiation TherapyInternational Journal of Radiation Oncology, Biology, PhysicsVol. 108Issue 3PreviewThis study aimed to identify vulnerable patients with head and neck cancer undergoing concurrent chemoradiation therapy (CCRT) who are susceptible to higher treatment-related adverse effects and have poorer treatment tolerance. This study also aimed to determine whether comprehensive geriatric assessment, developed in the geriatric population, can predict vulnerability to treatment-related adverse events and survival even in nongeriatric patients with head and neck cancer, as well as the prevalence of vulnerability and its effect on toxicities and survival among these patients. Full-Text PDF In Reply to Chow et alInternational Journal of Radiation Oncology, Biology, PhysicsVol. 108Issue 3PreviewWe appreciate the authors for their letter1 highlighting the complex issues of predicting survival and treatment toxicity in patients with head and neck cancer (HNC) before definitive chemoradiation therapy. Full-Text PDF
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