Improving an Intelligent Detection System for Coronary Heart Disease Using a Two-Tier Classifier Ensemble.

Abstract

Coronary heart disease (CHD) is one of the severe health issues and is one of the most common types of heart diseases. It is the most frequent cause of mortality across the globe due to the lack of a healthy lifestyle. Owing to the fact that a heart attack occurs without any apparent symptoms, an intelligent detection method is inescapable. In this article, a new CHD detection method based on a machine learning technique, e.g., classifier ensembles, is dealt with. A two-tier ensemble is built, where some ensemble classifiers are exploited as base classifiers of another ensemble. A stacked architecture is designed to blend the class label prediction of three ensemble learners, i.e., random forest, gradient boosting machine, and extreme gradient boosting. The detection model is evaluated on multiple heart disease datasets, i.e., Z-Alizadeh Sani, Statlog, Cleveland, and Hungarian, corroborating the generalisability of the proposed model. A particle swarm optimization-based feature selection is carried out to choose the most significant feature set for each dataset. Finally, a two-fold statistical test is adopted to justify the hypothesis, demonstrating that the performance differences of classifiers do not rely upon an assumption. Our proposed method outperforms any base classifiers in the ensemble with respect to 10-fold cross validation. Our detection model has performed better than current existing models based on traditional classifier ensembles and individual classifiers in terms of accuracy, F1, and AUC. This study demonstrates that our proposed model adds a considerable contribution compared to the prior published studies in the current literature.