Improved surgical outcomes following simultaneous pancreas-kidney transplantation in the contemporary era.

Abstract

Complications leading to early technical failure have been the Achilles' heel of simultaneous pancreas-kidney transplantation (SPKT). The study purpose was to analyze longitudinally our experience with early surgical complications following SPKT with an emphasis on changes in practice that improved outcomes in the most recent era. Single center retrospective review of all SPKTs from 11/1/01 to 8/12/20 with enteric drainage. Early relaparotomy was defined as occurring within 3 months of SPKT. Patients were stratified into two sequential eras: Era 1 (E1): 11/1/01-5/30/13; Era 2 (E2) 6/1/13-8/12/20 based on changes in practice that occurred pursuant to donor age and pancreas cold ischemia time (CIT). 255 consecutive SPKTs were analyzed (E1, n=165; E2, n=90). E1 patients received organs from older donors (mean E1 27.3vs. E2 23.1 years) with longer pancreas cold CITs) (mean E1 16.1vs. E2 13.3h, both p<.05). E1 patients had a higher early relaparotomy rate (E1 43.0%vs. E2 14.4%) and were more likely to require allograft pancreatectomy (E1 9.1%vs. E2 2.2%, both p<.05). E2 patients underwent systemic venous drainage more frequently (E1 8%vs. E2 29%) but pancreas venous drainage did not influence either relaparotomy or allograft pancreatectomy rates. The most common indications for early relaparotomy in E1 were allograft thrombosis (11.5%) and peri-pancreatic phlegmon/abscess (8.5%) whereas in E2 were thrombosis, pancreatitis/infection, and bowel obstruction (each 3%). Maximizing donor quality (younger donors) and minimizing pancreas CIT are paramount for reducing early surgical complications following SPKT.