Abstract
BACKGROUND: Although calcaneal broadband ultrasound attenuation (BUA) and speed of sound (SOS) are good predictors of osteoporotic fracture risk, BUA and SOS measurements exhibit substantial inter‐system variability. PURPOSE: 1) Compare phase insensitive (PI) detection, which suppresses phase cancellation, and conventional phase sensitive (PS) detection for measurement of BUA. 2) Test a new compensation formula for reducing variability in SOS measurements. METHODS: Data from 73 women were acquired using a GE Lunar Achilles Insight bone sonometer. Radio frequency data were processed off‐line using both PI and PS algorithms. RESULTS: BUA measurements (mean ± sd) were 81.4 ± 21.4 dB/MHz (PS) and 67.2 ± 9.7 dB/MHz (PI). Compensation of SOS measurements reduced 1) average transit‐time‐marker‐related SOS variability by 75% in 73 women and 2) bandwidth‐related SOS variability by 80% in a bone‐mimicking phantom. CONCLUSION: These new methods will enable a substantial improvement in consistency in bone sonometry. The mention of commercial products, their sources, or their use in connection with material reported herein is not to be construed as either an actual or implied endorsement of such products by the Department of Health and Human Services.
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