Abstract
covariates. During a median follow-up of 740 days, there was a strong association between change in Na level and survival (p for trend !0.001). In multivariable analysis, change in Na concentration was the strongest independent predictor of mortality (p 5 0.001; model c-statistic 0.758, 95% CI 0.702-0.813). Conclusion: Among patients hospitalized with HF and hyponatremia, change in serum Na concentration over time is a strong independent predictor of long-term survival. These data suggest that serum Na is a potential therapeutic target in patients with HF and hyponatremia.
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