Abstract
This study summarizes results from studies of behavior and visuomotor functions in monkeys (rhesus macaques) during development of parkinsonism-like syndrome induced by chronic administration of small doses of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). An operant conditioned reflex method was used to study the amplitude-time parameters of visually evoked saccades. Development of MPTP-induced syndrome was associated with increases in the latent periods of saccades, decreases in their peak velocities, and degradation of their accuracy. These oculomotor effects were apparent at the presymptomatic stage of MPTP syndrome, such that they can be regarded as early markers of parkinsonism-like syndrome in monkeys. The development of MPTP syndrome produced cognitive and motor deficits on execution of a spatially hindered operant task consisting of a food-procuring manipulation in peripersonal space.
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