Abstract

The amnestic type of mild cognitive impairment (aMCI) carries an increased risk of conversion to Alzheimer's disease (AD) and therefore its early identification is relevant for the development of disease-modifying treatments. Considering non-invasive simple diagnostic methods, we focused on visual evoked potentials (VEPs) as putative biomarker of cholinergic disfunction. We thus studied patients with MCI and AD by means of paired-pulse flash-visual evoked potentials (paired-F-VEPs). This technique, recently revived, analyses the overall excitability of visual system as detected from the cortical occipital signal.

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