Abstract
When offered a solution of d-amphetamine sulphate (0.025 mg/ml) in place of water, normal rats initially drank more drug solution per day than previously consumed water. The drug solution quickly became aversive to normal rats as daily intake decreased. Tolerance to the anorexic effect of d-amphetamine paralleled the decrease in daily drug intake. Rats with bilateral lesions of frontal cortex initially consumed as much drug solution and as much food as normal rats. Although frontal rats' daily intake of drug solution also decreased, an aversion never developed. Tolerance to d-amphetamine's anorexic effect took much longer to occur in frontal rats. The results indicated possible roles for both cumulative drug effects and conditioning factors in the response to chronic d-amphetamine use. A possible mechanism by which frontal cortical lesions interfered with chronic changes was suggested.
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