Abstract

Lymph node status is the most important prognostic factor in melanoma. Because regional spread to lymph nodes can occur in 20% of those with melanoma, the sentinel lymph node (SLN) biopsy has become a staging tool for isolating and sampling the draining lymph node basin for metastatic spread [1–7]. Refinements in the use of radioactive tracers for lymphatic mapping and the use of intraoperative gamma probes have resulted in a greater than 96% success rate for SLN biopsy. Despite these advances, there is a 2% to 6% incidence of false-negative (FN) SLN biopsies.

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