Abstract
The incidence of obesity and diabetes has been increased with alarming rate in recent years and became a common problem around the globe including developing as well as in developed countries with incalculable social costs. Obesity and type 2 diabetes are two common co-morbidities occur together. Obesity and diabetes is closely associated with many diseases, osteoarthritis, hypertension, certain form of cancer, sleep-breathing disorders and coronary heart disease. Impacts of obesity and diabetes (insulin resistance) on arthritis have been seen in patients that we associated with combination of various factors like increased availability of high- energy foods, genetic susceptibility and decreased physical activity in modern society. Arthritis is becoming pandemic around the globe and its occurrence with obesity and diabetes has been observed more common than ever. Combination of these two chronic conditions makes these diseases more vulnerable for human health. Till now very limited information is established about the pathological and mechanistic correlation among these health ailments. In this review article we aimed to survey the literature covering the influence of obesity and diabetes on arthritis pathology and tried to establish correlation with these diseases.
Highlights
Obesity and type 2 diabetes have become pandemic and most common health risks of the modern society throughout the world
Obesity and diabetes are well known for augmenting to number of diseases such as hypertension, coronary heart disease (CHD), osteoarthritis [5,6]
Various forms of arthritis are associated with obesity and diabetes, i.e. periodontal disease is a complication of diabetes mellitus which shows serious health hazard in arthritis cases
Summary
Most common health risks of the modern society throughout the world. These are chronic diseases with a multifactorial etiology carries to medical problems. Obesity and diabetes turn out to be a major public health issue and efforts to control their spread represent a priority of the public health agenda [7] It is coupled with bigger morbidity and mortality with an alarming rate [8]. Various forms of arthritis are associated with obesity and diabetes, i.e. periodontal disease is a complication of diabetes mellitus which shows serious health hazard in arthritis cases. Once this disease is established, the chronic features of this infection contribute to worsening disease status leading to more severe dia-. Among them inflammatory reactions are the important common factors that participate in the pathology of all three health ailments
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