Impact of inhalers used in the treatment of respiratory diseases on global warming.

Introduction and ObjectiveInhaled asthma therapy contributes to global warming but is currently a non-negotiable element of patient care. The carbon footprint of inhalers has previously been described. Pressurised metered dose...

Rapid reductions in greenhouse gas (GHG) emissions are vital to combat climate change. Healthcare systems contribute ~5% of global GHG emissions, with pressurised metered-dose inhalers (pMDIs) a significant contributor owing to their hydrofluorocarbon propellants. This study compared GHG emissions of a salbutamol pMDI using a low-carbon propellant in clinical development, hydrofluoroalkane (HFA)-152a, against current salbutamol inhalers. Three 'cradle-to-grave' lifecycle analyses compared GHG emissions of salbutamol pMDIs with HFA-152a and HFA-134a, and salbutamol dry-powder inhaler (DPI). Over 600 individual emission factors were calculated from > 2000 data points, and categorised into Active Pharmaceutical Ingredients Manufacture, Micronisation, Device, Formulation/Packaging, Use, Distribution and End-of-Life stages. 2023 manufacturing and supply data were collected from Algeria, Australia, Canada, France, Poland, Romania and Saudi Arabia. Carbon footprints were independently verified by the Carbon Trust. Mean total carbon footprint per salbutamol inhaler (based on 100-year global warming potential [GWP100]) was 26.91, 2.06 and 0.69 kgCO2e for HFA-134a pMDI, HFA-152a pMDI and DPI, respectively. This equated to a 92% reduction in total emissions for HFA-152a versus HFA-134a. Most pMDI emissions came from the Use stage (HFA-134a: 21.48 kgCO2e; HFA-152a: 1.45 kgCO2e). Per actuation, emissions were 135, 10 and 11 gCO2e, respectively. For each pMDI, GHG emissions were similar across countries. The low-GWP propellant, HFA-152a is expected to achieve > 90% reduction in the carbon footprint of salbutamol pMDI versus the currently used HFA-134a. The development of salbutamol pMDI with HFA-152a is a crucial step towards ensuring future patient access to salbutamol in a pMDI.

Summary Background: In bronchial challenge testing lung deposition of the stimulus may be poorly controlled due to incorrect use of nebulisers. Furthermore, the need for freshly prepared solutions burdens personnel and budget. In this study we aim to develop a dry powder alternative with higher reproducibility, better stability and lower costs than the current nebulisation test. Methods: Different pharmacological stimuli in the solid state were characterised on physico-chemical properties to determine the optimal conditions for processing and storage and were tested on their potential for dry powder inhalation. Adenosine and methacholine were micronised and dispersed with the Twincer ™ dry powder inhaler (DPI). Laser diffraction technique was applied to measure particle size distributions in the aerosol clouds. Results: Adenosine allows processing under ambient conditions. It was mixed with a lactose carrier in various mass ratios to produce adhesive mixtures and nucleus agglomerates. With three formulations, almost the entire dose range could be delivered with the Twincer ™ DPI. However, the process of preparing nucleus agglomerates might not be suitable for upscaling. Currently, spherical pellets are investigated as a more robust alternative. Methacholine is very hygroscopic and should therefore not be exposed to a high relative humidity. The methacholine particles leaving the Twincer ™ had an appropriate particle size distribution for inhalation. However, inhaler retention was high and should be reduced by controlling processing and storage conditions. Conclusions: Dry powder adenosine and methacholine seem promising alternatives for nebulisation. Methacholine must be handled under dry conditions. The highest doses of adenosine require further fine tuning.

PDF HTML阅读 XML下载 导出引用 引用提醒 基于生命周期评价的上海市水稻生产的碳足迹 DOI: 10.5846/stxb201304240794 作者: 作者单位: 上海市农业科学院,上海市农业科学院,上海市农业科学院,上海市农业科学院,江西农业大学 作者简介: 通讯作者: 中图分类号: 基金项目: 国家科技部支撑计划后世博专项资助项目（2010BAK69B18）；上海市科委崇明科技攻关专项资助项目（10DZ1960101） Life cycle assessment of carbon footprint for rice production in Shanghai Author: Affiliation: Shanghai Academy of Agricultural Sciences,Seed management station of Shanghai,,,Jiangxi Agricultural University Fund Project: 摘要 | 图/表 | 访问统计 | 参考文献 | 相似文献 | 引证文献 | 资源附件 | 文章评论 摘要:碳足迹是指由企业、组织或个人引起的碳排放的集合。参照PAS2050规范并结合生命周期评价方法对上海市水稻生产进行了碳足迹评估。结果表明：（1）目前上海市水稻生产的碳排放为11.8114 t CO2e/hm2，折合每吨水稻生产周期的碳足迹为1.2321 t CO2e；（2）稻田温室气体排放是水稻生产最主要的碳排放源，每吨水稻生产的总排放量为0.9507 t CO2e，占水稻生产全部碳排放的77.1%，其中甲烷（CH4）又是最主要的温室气体，对稻田温室气体碳排放的贡献率高达96.6%；（3）化学肥料的施用是第二大碳排放源，每吨水稻生产的总排放量为0.2044 t CO2e，占水稻生产总碳排放的16.5%，其中N最高，排放量为0.1159 t CO2e。因此，上海低碳水稻生产的关键在降低稻田甲烷的排放，另外可通过提高氮肥利用效率，减少氮肥施用等方法减少种植过程中碳排放。 Abstract:Global climate change has become an urgent issue of concern. Climate change will increasingly threaten our food production, security and even the survival of the human race. It also has a serious impact on natural ecosystems and the socioeconomic system. With the increasing scale and improvement in mechanization levels, the economic linkage between agricultural production and reduction of Greenhouse Gas (GHG) emissions is even closer in the agricultural production system. Therefore, the development of a low-carbon agricultural model is one of the long-term strategies for low-carbon economic growth throughout the country.This research of carbon footprint is introduced to measure the GHG emission over the rice production cycle. The carbon footprint can be defined as the total carbon emissions caused by an organization, event, product or person. At present, carbon footprints are used to measure GHG emissions in products, services, organizations, cities and countries and offer the decision basis for the formulation of GHG emission reduction schemes.Agricultural ecological systems, every year, also produce a lot of GHG emissions. The whole process of prenatal, intrapartum and postpartum agricultural production are closely related to energy consumption and GHG emission. In the process, all the agricultural inputs, such as chemical fertilizers, pesticides, seeds, cultivation, plant protection, agricultural machinery, irrigation and harvest also produce greenhouse gas emissions.The whole cultivation of rice involves methane (CH4) emission. This study shows that rice cultivation is one of the biggest sources of GHG emissions in crop cultivation. Rice paddies emit a large amount of methane in their water logged mode. Different irrigation modes have a great influence on the emission of GHG. Straw return is another factor that promotes GHG emissions. Soil organic content increases with the return of straw, with an increase in the soil methanogen activity, leading to increased methane emissions.The current carbon footprint research is the first time it has been used to measure the carbon emissions involved in rice production. The carbon footprint for rice production in Shanghai was assessed by the PAS2050 paradigm and life cycle assessment. The study area, located in Changjiang Farm, which belongs to the Guangming Group in Chongming County Shanghai City atlatitude 121°32'22' E, longitude31°40'23' N. Chongming County, in the Yangtze River Estuary, is a typical sub tropical monsoon climate with mild climate, abundant rainfall, annual average temperatures of 15.3 ℃, and annual precipitation of 1245 mm. It is the major grain production base for Shanghai city with winter wheat and summer rice forming their main planting patterns, which are typical for the middle and lower reaches of the Yangtze River rice-wheat rotation cropping pattern.The entire carbon emission of rice production in Shanghai was 11.8114 t CO2e (CO2-equivalents)/hm2, corresponding to a 1.2321 t CO2e/t rice grain yield. GHG emissions from paddy fields were the major source, which emitted 0.9507 t CO2e/t rice and accounted for 77.1% of total carbon emissions during rice production. Moreover, CH4 was the largest source for GHG emissions with a contribution rate of 96.6%.Chemical fertilizers were the second largest emission source in rice production. Chemical fertilizers emitted 0.2044 t CO2e for each ton of rice production, contributing 16.5% of total carbon emissions in rice production. N fertilizer was the biggest emission source, which released 0.1159 t CO2e/t rice.This research investigates the GHG emissions over the whole process of the Shanghai rice production cycle and reveals the energy consumption and GHG emissions in rice production. Thus, a rice carbon footprint is calculated by assessing the GHG emissions in Shanghai rice production. The results are beneficial for producing reduction plans of reducing GHG emissions in Shanghai rice production. Furthermore, the results will supply both practicable and theoretical foundations for drafting carbon footprint formulations in other industrial areas. 参考文献 相似文献 引证文献

<h3>Introduction and Objectives</h3> Pressurised metered dose inhalers (pMDIs) are an essential device option for patients with respiratory disease. However, due to the climate emergency, they face increased scrutiny due to the high global warming potential (GWP) of the propellant. Transition to pMDIs with next generation propellants (NGP) with a significantly lower GWP can provide a solution to support healthcare systems meet their carbon targets. In this work we show the reduction in greenhouse gas (GHG) emissions i.e. carbon footprint of a triple therapy pMDI with budesonide/glycopyrronium/formoterol fumarate dihydrate (BGF) realised by substituting the current propellant (HFA-134a) with candidate options HFA-152a or HFO-1234ze(E). <h3>Methods</h3> Cradle to grave life cycle inventory assessments of GHG emissions for this therapy were made using three propellants (HFA-134a, HFA-152a and HFO-1234ze(E)) aligned with ISO standards 14040 and 14044. GHG data were third party assured and considered variations resulting from the country of use, patient behaviour and disposal. In addition, four other key environmental impacts were quantified (freshwater use and ecotoxicity, resource and ozone depletion) and a comprehensive review was completed to understand the fate and effects of the candidate propellants and any transformation products to ensure holistic environmental due diligence. <h3>Results</h3> Substitution of HFA-134a with the selected NGP HFO-1234ze(E) would reduce the GWP of the propellant by &gt;99% resulting in a GHG emissions reduction for the whole pMDI device of at least 85%. Furthermore, other environmental impacts are reduced and the atmospheric transformation products are not of concern. <h3>Conclusions</h3> A pMDI using HFO-1234ze(E) would have GHG emissions typical of a dry powder inhaler (DPI) on a per dose basis. A change to a new propellant requires substantial investment, safety and clinical studies as well as regulatory approvals. Consequently, we estimate to transition to the new propellant in a portfolio of pMDI products across all markets, will take at least 5 years after the first product launch. However, a next generation of pMDIs with near-zero GWP propellant offers a way to resolve the climate and other environmental impacts posed by these devices without restricting patient choice or compromising clinical outcomes.

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ObjectivesMetered-dose inhalers (MDIs) contain propellants which are potent greenhouse gases. Many agencies propose a switch to alternative, low global warming potential (GWP) inhalers, such as dry powder inhalers (DPIs). We...

Aktualnie ważnym wyzwaniem dla sektora rolniczego jest redukcja emisji gazów cieplarnianych (GHG) w celu złagodzenia skutków zmian klimatycznych. Istnieje potrzeba dokładnej identyfikacji źródeł emisji oraz upowszechnienia praktyk rolniczych, które przyczyniałyby się do zmniejszenia emisji we wszystkich ogniwach produkcji roślinnej. Do przeprowadzenia obiektywnych porównań i wyboru najlepszych rozwiązań technologicznych według kryterium emisyjności potrzebna jest szczegółowa ocena ilościowa emisji GHG. W opracowaniu przedstawiono ocenę emisji GHG w produkcji roślinnej za pomocą śladu węglowego (CF). Udział operacji technologicznych w powstawaniu CF scharakteryzowano na przykładzie rzepaku ozimego. Wyniki badań wskazują, że największe znaczenie w kształtowaniu CF ma proces nawożenia mineralnego. Wpływ pozostałych procesów na CF jest wielokrotnie mniejszy. Miejscem głównych emisji GHG w nawożeniu mineralnym rzepaku są emisje bezpośrednie i pośrednie GHG z pól. Po emisjach GHG z pól, produkcja nawozów stanowi drugie źródło emisji z nawożenia. Zmiany praktyk rolniczych polegających na zwiększeniu efektywności nawożenia azotowego oraz stosowaniu nawozów o niskich współczynnikach emisji stwarzają obecnie możliwość redukcji emisji GHG i przez to, tym samym mogą przyczynić się do zmniejszenia CF produktów roślinnych.

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Better information on greenhouse gas (GHG) emissions and mitigation potential in the agricultural sector is necessary to manage these emissions and identify responses that are consistent with the food security and economic development priorities of countries. Critical activity data (what crops or livestock are managed in what way) are poor or lacking for many agricultural systems, especially in developing countries. In addition, the currently available methods for quantifying emissions and mitigation are often too expensive or complex or not sufficiently user friendly for widespread use.The purpose of this focus issue is to capture the state of the art in quantifying greenhouse gases from agricultural systems, with the goal of better understanding our current capabilities and near-term potential for improvement, with particular attention to quantification issues relevant to smallholders in developing countries. This work is timely in light of international discussions and negotiations around how agriculture should be included in efforts to reduce and adapt to climate change impacts, and considering that significant climate financing to developing countries in post-2012 agreements may be linked to their increased ability to identify and report GHG emissions (Murphy et al 2010, CCAFS 2011, FAO 2011).

The UK is aiming for net zero carbon emissions by 2050 and the NHS makes up roughly 5% of the total carbon footprint. Inhaler therapies have high potential for carbon...

The propellants in metered-dose inhalers (MDIs) are powerful greenhouse gases, which account for approximately 13% of the NHS's carbon footprint related to the delivery of care. Most MDI use is in salbutamol relievers in patients with poorly controlled disease. The UK lags behind Europe in this regard, with greater reliance on salbutamol MDI and correspondingly greater greenhouse gas emissions, roughly treble that of our European neighbours. There has been a broad switch towards MDIs in asthma treatment in the UK over the last 20 years to reduce financial costs, such that the treatment for two-thirds of asthma patients in the UK is dominated by salbutamol MDI. Strategies that replace overuse of reliever MDIs with regimes emphasising inhaled corticosteroids have the potential to improve asthma control alongside significant reductions in greenhouse gas emissions. Real-world evidence shows that once-daily long-acting combination dry-powder inhalers (DPIs) can improve compliance and asthma control, and reduce the carbon footprint of care. Similarly, maintenance and reliever therapy (MART), which uses combination reliever and inhaled steroids in one device (usually a DPI), can simplify therapy, improve asthma control and reduce greenhouse gas emissions. Both treatment strategies are popular with patients, most of whom would be willing to change treatment to reduce their carbon footprint. By focussing on patients who are currently using high amounts of salbutamol MDI and prioritising inhaled steroids via DPIs, there are golden opportunities to make asthma care in the UK more effective, safer and greener.

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