Abstract
Worldwide, influenza virus accounts for 7% of all acute lower respiratory tract infections, and 4% of deaths due to acute lower respiratory tract infections in children younger than 5 years.1 In The Lancet Infectious Diseases, Annette K Regan and colleagues2 report the results of an interesting multicentre, multicountry, surveillance study aiming to assess whether influenza vaccination is associated with illness attenuation. The study involved 41 sentinel sites across four countries in South America as part of REVELAC-i (Red para la Evaluación de Vacunas En Latino América y el Caribe—influenza), a network that annually evaluates influenza vaccine effectiveness using a test-negative design.
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