Abstract
The impact of dietary Ca on bone is well described in growing and mature mammals; however, less is known about Ca nutrition during the neonatal period. In order to further characterize the effects of neonatal Ca nutrition, we conducted a 14d Ca dose response feeding trial with 24 piglets (28±6 h of age). Pigs were limit fed liquid diets, containing either deficient, adequate, or excessive amounts of Ca (0.6, 0.9 or 1.3% Ca on a DM basis), in order to match the growth rate of sow‐reared controls. Blood was collected at d7 and d14 for determination of indicators of Ca status, and bones were collected for mineral content determination and for the isolation of MSC on d14. In vivo MSC proliferation was determined by an oral dose of BrdU 12h before tissue collection. Ca deficiency decreased growth rate, bone mineral content, and urinary Ca excretion (P<0.05). Excess dietary Ca had no effect on growth rate, but numerically increased bone mineral content, and increased (P<0.05) urinary Ca excretion compared to the Ca adequate group. Circulating PTH decreased (P<0.05) with increasing dietary Ca. Proliferation of MSC was greatest (P < 0.05) among pigs fed excess Ca. In vitro differentiation capabilities of MSC were significantly impacted based on Ca nutrition. The data suggest that neonatal Ca nutrition impacts bone development and may have long‐term consequences for bone health due to programming effects on MSC.
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