Abstract
AimThe aim of our experimental study was to determine the effect of exogenic nitrates on certain biological parameters in relation to renal insufficiency. ResultsChronic treatment of rats for 5 months with varying nitrate concentrations (50, 100, 150 and 500 mg/L) induced a dose-dependent reduction in plasma concentrations of total proteins and a dose-dependent increase in plasma urea concentrations and creatinine. DiscussionThis histological study of the kidney shows that nitrates at doses of 150 and 500 mg/L cause a deterioration in the epithelia of the renal tubules. ConclusionIn conclusion, a high nitrate intake induces morphofunctional disturbances of the kidney and could thus be regarded as a causative factor in renal insufficiency.
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