Abstract
Allergic reactions are caused by allergens belongs to the category of type-I hypersensitivity. The systemic release of histamine as a result of allergic reaction can be fatal anaphylaxis, creating a necessity to improve the efficiency of the treatment that is rendered to patients suffering from this hyper-sensitivity. The generally administered drugs include anti-histamine drugs, steroids and other oral medications but these drugs neutralizes the molecules released after the pseudo-infection, but not the misconception exercised by the immune system and only a temporary relief is achieved. An alternative is allergen immunotherapy, in which the patient is treated with a large dosage of the allergens leading to hyposensitization to the allergens. However anaphylaxis may happen. Hence, monitoring this treatment is vital. In this paper, the methodology of immunotherapy monitoring is given. The monitoring is carried out by liposomes that are made to carry address tags-monoclonal antibodies. The liposomes envelop the histamine molecules, which are emitted on reaching target site and designed in such a way that they emit fluorescence on enveloping histamine. Increased histamine secretion (higher amount of fluorescence) denotes the inefficacy of the treatment and suppressed levels denote otherwise, hence can be used as an online biosensor. This paper deals with subsequent monitoring of the same, thereby avoiding further complications.
Highlights
Liposomes are artificially prepared vesicles made of lipid bilayer
Anaphylaxis is defined as a serious allergic reaction that is rapid in onset and may cause death
This proposal is not allergy-specific, i.e., this methodology can be used while treating any allergy, be it food allergy, medication allergy, insect allergy or environmental causative agents
Summary
Liposomes are artificially prepared vesicles made of lipid bilayer. They can be filled with drugs for cancer and other diseases. There are three types of liposomes: MLV (Multilamellar Vesicles) SUV (Small Unilamellar Vesicles) and LUV (Large Unilamellar Vesicles) These are used to deliver different types of drugs. Liposomes, which use a form nanotechnology science, impressively and harmoniously, use the generalized nature of the liposomes themselves to increase the efficacy, bioavailability, absorption, and delivery of these certain entrapped dietary and nutritional supplements. This generalized nature and makeup of liposomes, being composed of phospholipids, adroitly complements the natural lining of nearly every cell within the human body. The quality of raw lipid used in the preparation and manufacturing of the liposomes precisely co-relates to this natural congruency between the liposomes and the cells of the human body
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