Abstract
The distinction between benign and malignant lymphoid infiltrates in the skin may be difficult. Helpful histologic criteria exist, 1 but in many cases differentiation of benign from malignant infiltrates is aided by special techniques. Recently, many advances have been made in the characterization of lymphoid infiltrates by the use of cellular immunophenotyping. An expanding knowledge of the normal sequence of hematopoetic cell maturation and accompanying antigen expression has considerably aided the understanding of benign and malignant infiltrates. The concept that a lymphoid malignancy is phenotypically related to a normal leukocyte counterpart allows the identification of aberrant antigen expression. In this chapter, we will discuss technical considerations of the immunoperoxidase method and review the immunophenotypes of certain benign and malignant cutaneous infiltrates.
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