IMMUNOLOGICAL REACTIVITY IN MEGAPOLIS RESIDENTS

Abstract

Introduction: Living in an urban environment with a high population density, time pressure, increased frequency of involuntary social contacts privacy violation, lack of recreation areas may lead to not only mental health disorders, but also to somatic diseases. The evidence on the state of immune homeostasis of residents of the urbanized environment is limited. Aim: To assess immunological reactivity in residents of a megapolis. Methods: We assessed phagocytic activity, phenotypes of lymphocytes CD3+, CD5+, CD4+, CD8+, CD10+, cytokines IL-1β, IL-2, TNF-α, immunoglobulins IgA, IgM, IgE, IgG and carcinoembryonic antigen in a sample of 40-60 years old healthy residents of Moscow. Results: The analysis showed that in 83.33% of subjects the ratios of lymphoproliferation and differentiation of lymphoid populations were in balance. There was no deficiency of either CD8+ immunosuppressors or CD4+ T-helpers. Concentrations of lymphoid cells with receptors to interleukin - 2 (CD25+) were detected within the physiological standard in 98.79 % of the study participants. It was found that in 8.13 % of individuals the increased content of mature functional CD3+ lymphocytes was associated with greater concentrations of immunoglobulin E, but within physiological limits. Conclusion: The most common immune defense defect in 40-60-year-old residents of the metropolis is a deficiency in serum IgA (76,04 %) and mature T-lymphocytes (51,04 %) in peripheral blood