Abstract
Cell-mediated immunological function was studied in 18 patients with dilated cardiomyopathy (DCM) making use of peripheral blood lymphocytes (PBL). The results were as follows: 1) Blastoid transformation of PBL stimulated with phytohemagglutinin (PHA) was significantly suppressed in patients with DCM compared with normal controls (p less than 0.01). 2) The T-cell subset ratio of Leu-3a-positive cells to Leu-2a-positive cells was significantly higher in patients with DCM than that in the control group (p less than 0.05). 3) Interleukin-2 (IL-2) production of PBL under PHA stimulation was enhanced significantly in patients with DCM (p less than 0.05). 4) IL-2 receptor-positive cells were significantly fewer in number in patients with DCM than in controls (p less than 0.05). These results suggest that immunological disorders including changes in the IL-2 system are present in some patients with DCM and may play a role in the occurrence of DCM.
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