Abstract
Immunologic responses were determined in mice following silica or olivine inhalations of up to 300 days, or following intravenous (iv) and intraperitoneal (ip) injections of the dusts. The comparative toxicity of iv injected silica or olivine was also studied. Silica inhalation suppressed the splenic plaque-forming cell (PFC) responses to Escherichia coli given as an aerosol, while olivine inhalation caused less severe suppression. Similar decreases in specific serum antibody levels and alveolar macrophage phagocytic indices were also seen. Few changes were found in spleen lymphocyte responses to mitogens. Injections of silica (iv or ip) caused either enhancement, or in some cases suppression, of the response to antigenic stimulation, with lower doses generally stimulating and very high doses suppressing the response. Olivine injections, in general, produced similar but less severe alterations of the responses to antigenic stimulations. Comparison of lethal dose levels by iv injection indicated a greater toxicity for silica than olivine in this respect.
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