Abstract
Prostate-specific antigen (PSA), a glycoprotein initially thought to be produced only by the epithelial cells of the prostate, has recently been found in 30% of female breast tumours using immunofluorometry. Our aim was to localize PSA immunohistochemically in a selected group of 27 paraffin-embedded breast tissues. A scoring system was developed for the histological assessment of PSA positivity within the breast tissue. One pathologist (DH) scored, classified and graded all tumours. Site-specific PSA staining was noted in the histology slides. Intense staining was identified in apocrine metaplasia and within the lining ductal epithelium of cystically dilated ducts. The epithelium in lesions of sclerosing adenosis was also frequently positive for PSA staining. Hyperplastic ductal epithelium (especially of mild degree) occasionally stained positive, as did normal breast ducts. Better differentiated tumours showed PSA staining [e.g. mucinous carcinoma (colloid)]. If an infiltrating duct carcinoma showed staining for PSA, adjacent intraductal carcinoma was also noted to stain positively, if present.
Highlights
Twenty-seven female breast tissues were chosen from a group that had been previously assayed for Prostate-specific antigen (PSA) immunofluorometrically (Diamandis et al, 1994)
The proliferating epithelium in the fibroadenoma as well as the cysts in the fibrocystic changes both exhibited a significant degree of PSA staining immunohistochemically
Apocrine metaplastic epithelium stained intensely positive for PSA
Summary
Our aim was to localize PSA immunohistochemically in a selected group of 27 paraffin-embedded breast tissues. Our aim was to localize PSA by immunohistochemistry in 27 breast tissues selected to be either positive or negative for PSA by immunofluorometry
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