Abstract
Objective Analyze for the first time the immunohistochemical expression in tooth germ (TG) ameloblastoma (AM), ameloblastic carcinoma (AC), ameloblastic fibroma (AF) and ameloblastic fibrosarcoma (AFS) of fatty acid synthase (fasn) and cyclooxygenase (cox-2), which are highly associated to tumorigenic events and poor prognosis in several types of cancer and also are promising chemotherapy targets. Study Design Immunohistochemistry for fasn and cox-2 was performed in 10 TG, 44 solid or conventional AM, 10 AC, 9 AF, and 5 AFS. Results were analyzed using the Immunoreactive Score (IRS). Results Most TG were strongly positive for fasn and negative or weakly positive for cox-2. All AM and AC expressed fasn and cox-2. AC showed higher expression of both markers. In AF, fasn and cox-2 were variably expressed in epithelium and negative in the mesenchyme, while in AFS, the mesenchymal malignant component was strongly positive for fasn, whereas cox-2 was negative in both components. Conclusions The coexpression of fasn and cox-2 may be involved in the pathogenesis and behavior of AM and AC, while in AFS only fasn seems to play a role in the sarcomatous component. These markers could be a potential therapeutic target in the future; however, further studies are necessary.
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